| 2. Jornada | 10.08.2021 | Chavelines Juniors | - | Santos FC | 3:0 |  |
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| 3. Jornada | 13.08.2021 | Santos FC | - | Deportivo Coopsol | 1:4 | ||||
| 4. Jornada | 20.08.2021 | Juan Aurich | - | Santos FC | 2:2 | ||||
| 5. Jornada | 26.08.2021 | Santos FC | - | Pirata | 2:0 | ||||
| 7. Jornada | 07.09.2021 | Santos FC | - | Atlético Grau | 0:0 | ||||
| 9. Jornada | 16.09.2021 | Llacuabamba | - | Santos FC | 0:2 | ||||
| 10. Jornada | 21.09.2021 | Santos FC | - | Los Chankas | 0:1 | ||||
| 11. Jornada | 30.09.2021 | Carlos Stein | - | Santos FC | 3:0 |
Colombia