| 1. Jornada | 23.01.2022 | Tigres FC | - | Real Cartagena | 1:2 | ||||
| 2. Jornada | 30.01.2022 | Real Santander | - | Tigres FC | 0:0 | ||||
| 3. Jornada | 05.02.2022 | Tigres FC | - | Atlético FC | 1:1 | ||||
| 4. Jornada | 13.02.2022 | Leones FC | - | Tigres FC | 3:1 | ||||
| 5. Jornada | 18.02.2022 | Tigres FC | - | Bogotá FC | 3:0 | ||||
| 7. Jornada | 06.03.2022 | Tigres FC | - | Llaneros FC | 0:1 | ||||
| 8. Jornada | 11.03.2022 | Deportes Quindío | - | Tigres FC | 0:0 | ||||
| 9. Jornada | 22.03.2022 | Tigres FC | - | Boyacá Chicó | 1:0 | ||||
| 10. Jornada | 26.03.2022 | Boca Juniors de Cali | - | Tigres FC | 2:0 | ||||
| 11. Jornada | 03.04.2022 | Tigres FC | - | Valledupar FC | 3:2 | ||||
| 13. Jornada | 16.04.2022 | Fortaleza FC | - | Tigres FC | 1:2 | ||||
| 14. Jornada | 25.04.2022 | Tigres FC | - | Barranquilla FC | 2:0 | ||||
| 15. Jornada | 04.05.2022 | Atlético Huila | - | Tigres FC | 0:0 |
Colombia