| 1. Jornada | 17.08.2018 | FC Twente | - | Sparta Rotterdam | 2:1 | ||||
| 3. Jornada | 31.08.2018 | FC Twente | - | Roda JC Kerkrade | 3:1 | ||||
| 7. Jornada | 30.09.2018 | FC Twente | - | Jong PSV | 2:1 | ||||
| 9. Jornada | 14.10.2018 | FC Twente | - | MVV | 0:1 | ||||
| 10. Jornada | 22.10.2018 | FC Utrecht (J) | - | FC Twente | 1:6 | ||||
| 11. Jornada | 26.10.2018 | FC Twente | - | Almere City FC | 1:0 | ||||
| 12. Jornada | 02.11.2018 | FC Twente | - | RKC Waalwijk | 3:1 | ||||
| 20. Jornada | 13.01.2019 | MVV | - | FC Twente | 0:2 | ||||
| 24. Jornada | 08.02.2019 | Sparta Rotterdam | - | FC Twente | 0:3 | ||||
| 25. Jornada | 18.02.2019 | Jong PSV | - | FC Twente | 0:2 | ||||
| 27. Jornada | 01.03.2019 | Roda JC Kerkrade | - | FC Twente | 1:1 |  |
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| 29. Jornada | 15.03.2019 | FC Twente | - | FC Volendam | 5:0 | ||||
| 30. Jornada | 24.03.2019 | Go Ahead Eagles | - | FC Twente | 1:2 |  |
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| 31. Jornada | 29.03.2019 | FC Twente | - | FC Den Bosch | 1:0 | ||||
| 32. Jornada | 01.04.2019 | RKC Waalwijk | - | FC Twente | 4:1 | ||||
| 33. Jornada | 05.04.2019 | FC Twente | - | FC Dordrecht | 0:1 | ||||
| 34. Jornada | 12.04.2019 | FC Twente | - | Telstar | 1:0 | ||||
| 35. Jornada | 29.04.2019 | Jong Ajax | - | FC Twente | 2:5 |  |
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| 38. Jornada | 03.05.2019 | FC Twente | - | SC Cambuur | 2:2 |
Países Bajos