| 1. Jornada | 06.08.2021 | Telstar | - | FC Emmen | 1:1 |  |
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| 2. Jornada | 13.08.2021 | FC Emmen | - | FC Eindhoven | 0:1 | ||||
| 3. Jornada | 20.08.2021 | ADO Den Haag | - | FC Emmen | 1:2 | |
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| 4. Jornada | 27.08.2021 | FC Emmen | - | De Graafschap | 0:2 | ||||
| 5. Jornada | 03.09.2021 | Helmond Sport | - | FC Emmen | 1:0 | ||||
| 6. Jornada | 10.09.2021 | FC Emmen | - | MVV | 7:1 | |
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| 7. Jornada | 17.09.2021 | NAC Breda | - | FC Emmen | 1:2 | ||||
| 8. Jornada | 24.09.2021 | FC Emmen | - | FC Den Bosch | 2:0 | ||||
| 9. Jornada | 01.10.2021 | FC Utrecht (J) | - | FC Emmen | 0:1 | ||||
| 10. Jornada | 09.10.2021 | FC Emmen | - | SBV Excelsior | 0:1 |  |
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| 11. Jornada | 15.10.2021 | TOP Oss | - | FC Emmen | 1:2 | ||||
| 12. Jornada | 23.10.2021 | Roda JC Kerkrade | - | FC Emmen | 1:2 | ||||
| 13. Jornada | 29.10.2021 | FC Emmen | - | VVV-Venlo | 1:0 | |
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| 14. Jornada | 05.11.2021 | FC Volendam | - | FC Emmen | 2:2 | |
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| 16. Jornada | 19.11.2021 | FC Emmen | - | Jong PSV | 2:0 | ||||
| 15. Jornada | 22.11.2021 | AZ Alkmaar (J) | - | FC Emmen | 0:0 | ||||
| 17. Jornada | 29.11.2021 | FC Emmen | - | Almere City FC | 3:0 | ||||
| 18. Jornada | 06.12.2021 | Jong Ajax | - | FC Emmen | 1:0 | ||||
| 19. Jornada | 10.12.2021 | FC Emmen | - | FC Dordrecht | 2:1 | ||||
| 20. Jornada | 17.12.2021 | MVV | - | FC Emmen | 0:1 |
Países Bajos