| 3. Jornada | 15.08.2021 | Lobos UPNFM | - | Honduras Progreso | 3:0 | ||||
| 4. Jornada | 22.08.2021 | Lobos UPNFM | - | Platense | 3:0 |  |
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| 5. Jornada | 26.08.2021 | Real España | - | Lobos UPNFM | 5:3 | ||||
| 6. Jornada | 31.08.2021 | Motagua | - | Lobos UPNFM | 0:0 | ||||
| 8. Jornada | 12.09.2021 | Lobos UPNFM | - | Olimpia | 0:0 | ||||
| 9. Jornada | 15.09.2021 | Lobos UPNFM | - | Real Sociedad | 2:0 | ||||
| 12. Jornada | 04.10.2021 | Lobos UPNFM | - | Marathón | 1:1 | ||||
| 14. Jornada | 17.10.2021 | Honduras Progreso | - | Lobos UPNFM | 0:1 | ||||
| 17. Jornada | 31.10.2021 | Olimpia | - | Lobos UPNFM | 2:1 | ||||
| 18. Jornada | 10.11.2021 | Victoria | - | Lobos UPNFM | 1:0 |
Honduras