| 5. Jornada | 25.08.2021 | Real Cartagena | - | Cortuluá | 2:0 |  |
|||
| 6. Jornada | 31.08.2021 | Unión Magdalena | - | Real Cartagena | 1:0 | ||||
| 7. Jornada | 04.09.2021 | Real Cartagena | - | Boca Juniors de Cali | 2:0 | ||||
| 9. Jornada | 19.09.2021 | Leones FC | - | Real Cartagena | 2:0 | ||||
| 10. Jornada | 29.09.2021 | Real Cartagena | - | Llaneros FC | 2:1 | ||||
| 11. Jornada | 06.10.2021 | Tigres FC | - | Real Cartagena | 1:2 | |
|||
| 12. Jornada | 12.10.2021 | Real Cartagena | - | Barranquilla FC | 3:1 |  |
|||
| 14. Jornada | 26.10.2021 | Real Cartagena | - | Atlético FC | 1:1 | ||||
| 15. Jornada | 30.10.2021 | Orsomarso SC | - | Real Cartagena | 1:1 |
Colombia