| 2. Jornada | 22.08.2021 | Southampton | - | Manchester United | 1:1 | ||||
| 4. Jornada | 11.09.2021 | Manchester United | - | Newcastle United | 4:1 |  |
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| 5. Jornada | 19.09.2021 | West Ham United | - | Manchester United | 1:2 | |
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| 8. Jornada | 16.10.2021 | Leicester City | - | Manchester United | 4:2 | ||||
| 10. Jornada | 30.10.2021 | Tottenham Hotspur | - | Manchester United | 0:3 | ||||
| 12. Jornada | 20.11.2021 | Watford FC | - | Manchester United | 4:1 | ||||
| 13. Jornada | 28.11.2021 | Chelsea | - | Manchester United | 1:1 | ||||
| 14. Jornada | 02.12.2021 | Manchester United | - | Arsenal | 3:2 | ||||
| 22. Jornada | 15.01.2022 | Aston Villa | - | Manchester United | 2:2 | ||||
| 24. Jornada | 08.02.2022 | Burnley FC | - | Manchester United | 1:1 | ||||
| 25. Jornada | 12.02.2022 | Manchester United | - | Southampton | 1:1 |  |
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| 26. Jornada | 20.02.2022 | Leeds United | - | Manchester United | 2:4 | ||||
| 28. Jornada | 06.03.2022 | Manchester City | - | Manchester United | 4:1 | ||||
| 33. Jornada | 16.04.2022 | Manchester United | - | Norwich City | 3:2 | ||||
| 30. Jornada | 19.04.2022 | Liverpool | - | Manchester United | 4:0 | ||||
| 34. Jornada | 23.04.2022 | Arsenal | - | Manchester United | 3:1 |
Inglaterra
San Vicente y las Granadinas 
