| 3. Jornada | 06.02.2022 | Barranquilla FC | - | Real Cartagena | 0:2 | ||||
| 4. Jornada | 13.02.2022 | Real Santander | - | Barranquilla FC | 2:3 | ||||
| 6. Jornada | 27.02.2022 | Leones FC | - | Barranquilla FC | 3:1 | ||||
| 7. Jornada | 06.03.2022 | Barranquilla FC | - | Bogotá FC | 2:4 | ||||
| 8. Jornada | 10.03.2022 | Orsomarso SC | - | Barranquilla FC | 2:1 | ||||
| 11. Jornada | 03.04.2022 | Barranquilla FC | - | Boyacá Chicó | 2:2 | ||||
| 9. Jornada | 06.04.2022 | Barranquilla FC | - | Llaneros FC | 1:2 | ||||
| 12. Jornada | 11.04.2022 | Boca Juniors de Cali | - | Barranquilla FC | 0:0 | ||||
| 13. Jornada | 16.04.2022 | Barranquilla FC | - | Valledupar FC | 1:1 | ||||
| 14. Jornada | 25.04.2022 | Tigres FC | - | Barranquilla FC | 2:0 | ||||
| 15. Jornada | 04.05.2022 | Barranquilla FC | - | Fortaleza FC | 0:1 |
Colombia