| 3. Jornada | 21.02.2025 | Alianza | - | Sporting San Miguelito | 1:2 |  |
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| 6. Jornada | 23.02.2025 | Sporting San Miguelito | - | Herrera FC | 2:0 | ||||
| 7. Jornada | 27.02.2025 | Sporting San Miguelito | - | Veraguas United | 2:2 | ||||
| 8. Jornada | 09.03.2025 | Independiente de La Chorrera | - | Sporting San Miguelito | 4:0 | ||||
| 10. Jornada | 23.03.2025 | UD Universitario | - | Sporting San Miguelito | 1:0 | |
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| 12. Jornada | 07.04.2025 | Tauro FC | - | Sporting San Miguelito | 0:1 | ||||
| 13. Jornada | 14.04.2025 | Sporting San Miguelito | - | Árabe Unido | 1:0 | ||||
| 16. Jornada | 11.05.2025 | Sporting San Miguelito | - | Plaza Amador | 0:1 |
Panamá