| 7. Jornada | 14.08.2022 | Santa Fe | - | Deportes Tolima | 2:1 | ||||
| 8. Jornada | 21.08.2022 | Independiente Medellín | - | Santa Fe | 2:0 |  |
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| 9. Jornada | 27.08.2022 | Santa Fe | - | Patriotas FC | 2:1 | |
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| 10. Jornada | 04.09.2022 | Millonarios | - | Santa Fe | 2:0 | ||||
| 11. Jornada | 11.09.2022 | Santa Fe | - | Deportivo Pasto | 2:1 | ||||
| 12. Jornada | 17.09.2022 | Atlético Bucaramanga | - | Santa Fe | 2:1 | ||||
| 13. Jornada | 30.09.2022 | Santa Fe | - | Atlético Nacional | 1:1 | |
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| 15. Jornada | 03.10.2022 | Santa Fe | - | Envigado FC | 1:0 | ||||
| 16. Jornada | 11.10.2022 | Alianza Petrolera | - | Santa Fe | 4:0 | ||||
| 18. Jornada | 17.10.2022 | Jaguares de Córdoba | - | Santa Fe | 2:1 | |
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| 19. Jornada | 22.10.2022 | Santa Fe | - | Deportivo Cali | 1:0 | |
Colombia