| 3. Jornada | 22.01.2021 | Atlético San Luis | - | Deportivo Guadalajara | 3:1 | ||||
| 4. Jornada | 02.02.2021 | Club León | - | Atlético San Luis | 3:1 |  |
|||
| 5. Jornada | 05.02.2021 | Atlético San Luis | - | Club Tijuana | 2:2 | ||||
| 8. Jornada | 26.02.2021 | Atlético San Luis | - | UANL Tigres | 2:2 | ||||
| 11. Jornada | 15.03.2021 | Gallos Blancos | - | Atlético San Luis | 2:1 | ||||
| 16. Jornada | 25.04.2021 | Cruz Azul | - | Atlético San Luis | 3:2 |
Colombia