| 2. Jornada | 23.01.2021 | Leones FC | - | Fortaleza FC | 0:0 | ||||
| 3. Jornada | 31.01.2021 | Leones FC | - | Tigres FC | 1:2 |  |
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| 4. Jornada | 05.02.2021 | Atlético Huila | - | Leones FC | 1:1 | ||||
| 5. Jornada | 10.02.2021 | Leones FC | - | Cortuluá | 1:1 | ||||
| 6. Jornada | 13.02.2021 | Atlético FC | - | Leones FC | 2:3 | ||||
| 1. Jornada | 18.02.2021 | Bogotá FC | - | Leones FC | 1:3 | ||||
| 7. Jornada | 22.02.2021 | Leones FC | - | Barranquilla FC | 2:1 | |
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| 8. Jornada | 27.02.2021 | Valledupar FC | - | Leones FC | 0:1 | ||||
| 9. Jornada | 03.03.2021 | Leones FC | - | Llaneros FC | 1:0 | ||||
| 10. Jornada | 09.03.2021 | Unión Magdalena | - | Leones FC | 2:0 | ||||
| 11. Jornada | 14.03.2021 | Leones FC | - | Deportes Quindío | 0:2 | ||||
| 12. Jornada | 22.03.2021 | Orsomarso SC | - | Leones FC | 1:1 | |
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| 13. Jornada | 28.03.2021 | Leones FC | - | Boca Juniors de Cali | 2:0 | ||||
| 14. Jornada | 03.04.2021 | Real Cartagena | - | Leones FC | 2:1 | |
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| 15. Jornada | 09.04.2021 | Leones FC | - | Real Santander | 2:0 |
Colombia