| 1. Jornada | 05.02.2022 | Defensor Sporting | - | Liverpool | 0:3 | ||||
| 4. Jornada | 26.02.2022 | Montevideo Wanderers | - | Defensor Sporting | 1:0 | ||||
| 6. Jornada | 21.03.2022 | Boston River | - | Defensor Sporting | 1:1 | ||||
| 10. Jornada | 26.04.2022 | Defensor Sporting | - | Cerrito | 0:0 | ||||
| 11. Jornada | 07.05.2022 | Albion | - | Defensor Sporting | 0:3 | ||||
| 15. Jornada | 05.06.2022 | Rentistas | - | Defensor Sporting | 1:0 |
Uruguay