| 1. Jornada | 15.08.2021 | Lommel SK | - | Waasland-Beveren | 2:3 |  |
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| 2. Jornada | 22.08.2021 | Waasland-Beveren | - | KMSK Deinze | 0:2 | ||||
| 3. Jornada | 29.08.2021 | Royal Excel Mouscron | - | Waasland-Beveren | 0:4 | ||||
| 4. Jornada | 12.09.2021 | Waasland-Beveren | - | KVC Westerlo | 0:2 | ||||
| 5. Jornada | 17.09.2021 | RWD Molenbeek | - | Waasland-Beveren | 1:3 | ||||
| 6. Jornada | 24.09.2021 | Lierse Kempenzonen | - | Waasland-Beveren | 2:1 | ||||
| 7. Jornada | 03.10.2021 | Waasland-Beveren | - | Excelsior Virton | 4:3 |  |
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| 8. Jornada | 15.10.2021 | KMSK Deinze | - | Waasland-Beveren | 0:0 | ||||
| 9. Jornada | 24.10.2021 | Waasland-Beveren | - | Lommel SK | 2:1 | ||||
| 10. Jornada | 30.10.2021 | Waasland-Beveren | - | Lierse Kempenzonen | 1:3 | ||||
| 11. Jornada | 07.11.2021 | KVC Westerlo | - | Waasland-Beveren | 1:1 | ||||
| 12. Jornada | 19.11.2021 | Waasland-Beveren | - | Royal Excel Mouscron | 0:2 | ||||
| 13. Jornada | 26.11.2021 | Excelsior Virton | - | Waasland-Beveren | 0:3 | ||||
| 14. Jornada | 04.12.2021 | Waasland-Beveren | - | RWD Molenbeek | 2:3 | |
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| 15. Jornada | 12.12.2021 | Waasland-Beveren | - | KMSK Deinze | 4:1 | ||||
| 16. Jornada | 17.12.2021 | Lommel SK | - | Waasland-Beveren | 1:1 |
Estados Unidos