| 2. Jornada | 15.08.2021 | CS FOLA Esch | - | Etzella Ettelbruck | 2:0 | ||||
| 3. Jornada | 22.08.2021 | Etzella Ettelbruck | - | UNA Strassen | 2:3 | ||||
| 5. Jornada | 12.09.2021 | Etzella Ettelbruck | - | FC Rodange 91 | 3:0 | ||||
| 6. Jornada | 18.09.2021 | RM Hamm Benfica | - | Etzella Ettelbruck | 1:3 | ||||
| 7. Jornada | 22.09.2021 | Etzella Ettelbruck | - | FC Wiltz 71 | 3:1 | ||||
| 8. Jornada | 26.09.2021 | F91 Dudelange | - | Etzella Ettelbruck | 6:1 | ||||
| 9. Jornada | 17.10.2021 | Etzella Ettelbruck | - | Jeunesse Esch | 2:1 |  |
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| 11. Jornada | 07.11.2021 | Etzella Ettelbruck | - | RFCU Luxemburg | 1:2 | ||||
| 12. Jornada | 21.11.2021 | Union Titus Pétange | - | Etzella Ettelbruck | 4:1 | ||||
| 13. Jornada | 28.11.2021 | Etzella Ettelbruck | - | US Mondorf | 2:1 | ||||
| 15. Jornada | 12.12.2021 | FC Differdange 03 | - | Etzella Ettelbruck | 4:0 | ||||
| 29. Jornada | 15.05.2022 | Etzella Ettelbruck | - | FC Differdange 03 | 0:2 | ||||
| 30. Jornada | 22.05.2022 | Victoria Rosport | - | Etzella Ettelbruck | 0:3 |
Luxemburgo