| 2. Jornada | 11.08.2021 | Marathón | - | Lobos UPNFM | 5:1 | ||||
| 3. Jornada | 14.08.2021 | Marathón | - | Motagua | 2:0 | ||||
| 4. Jornada | 22.08.2021 | Vida | - | Marathón | 2:0 | ||||
| 6. Jornada | 29.08.2021 | Marathón | - | Real España | 0:1 | ||||
| 7. Jornada | 04.09.2021 | Marathón | - | Real Sociedad | 2:1 | ||||
| 8. Jornada | 12.09.2021 | Victoria | - | Marathón | 1:0 | ||||
| 11. Jornada | 25.09.2021 | Marathón | - | Vida | 1:2 | ||||
| 13. Jornada | 09.10.2021 | Marathón | - | Honduras Progreso | 2:1 | ||||
| 14. Jornada | 18.10.2021 | Motagua | - | Marathón | 2:1 |
Honduras