| 1. Jornada | 20.01.2022 | Olimpia | - | Real Sociedad | 4:2 | ||||
| 2. Jornada | 23.01.2022 | Victoria | - | Real Sociedad | 2:0 | ||||
| 3. Jornada | 06.02.2022 | Real Sociedad | - | Lobos UPNFM | 2:2 | ||||
| 5. Jornada | 14.02.2022 | Real España | - | Real Sociedad | 4:1 | ||||
| 9. Jornada | 06.03.2022 | Real Sociedad | - | Motagua | 2:1 | ||||
| 10. Jornada | 13.03.2022 | Lobos UPNFM | - | Real Sociedad | 1:0 | ||||
| 12. Jornada | 03.04.2022 | Honduras Progreso | - | Real Sociedad | 0:1 |  |
Honduras