| 1. Jornada | 01.08.2022 | Real España | - | Lobos UPNFM | 1:0 |  |
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| 2. Jornada | 07.08.2022 | Lobos UPNFM | - | Real Sociedad | 2:0 | ||||
| 3. Jornada | 11.08.2022 | Victoria | - | Lobos UPNFM | 4:0 | |
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| 5. Jornada | 21.08.2022 | Lobos UPNFM | - | Motagua | 2:3 |  |
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| 6. Jornada | 29.08.2022 | Olimpia | - | Lobos UPNFM | 2:0 | ||||
| 7. Jornada | 01.09.2022 | Lobos UPNFM | - | Olancho FC | 1:2 | ||||
| 8. Jornada | 04.09.2022 | Marathón | - | Lobos UPNFM | 1:1 | ||||
| 9. Jornada | 11.09.2022 | Vida | - | Lobos UPNFM | 2:1 | ||||
| 10. Jornada | 19.09.2022 | Lobos UPNFM | - | Real España | 2:2 | ||||
| 11. Jornada | 02.10.2022 | Real Sociedad | - | Lobos UPNFM | 0:2 | ||||
| 12. Jornada | 09.10.2022 | Lobos UPNFM | - | Victoria | 2:2 | |
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| 13. Jornada | 16.10.2022 | Honduras Progreso | - | Lobos UPNFM | 2:2 | ||||
| 14. Jornada | 21.10.2022 | Motagua | - | Lobos UPNFM | 2:2 | ||||
| 15. Jornada | 24.10.2022 | Lobos UPNFM | - | Olimpia | 0:0 | ||||
| 16. Jornada | 06.11.2022 | Olancho FC | - | Lobos UPNFM | 3:0 | ||||
| 17. Jornada | 14.11.2022 | Lobos UPNFM | - | Marathón | 2:1 | |
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| 18. Jornada | 19.11.2022 | Lobos UPNFM | - | Vida | 3:2 | |
Honduras