| 1. Jornada | 01.08.2021 | Alianza | - | Municipal Limeño | 4:1 |  |
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| 2. Jornada | 08.08.2021 | Platense Zacatecoluca | - | Alianza | 2:2 | ||||
| 4. Jornada | 15.08.2021 | Alianza | - | Luis Ángel Firpo | 2:2 | |
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| 7. Jornada | 29.08.2021 | Isidro Metapán | - | Alianza | 1:2 | ||||
| 8. Jornada | 12.09.2021 | Alianza | - | Atlético Marte | 3:1 |  |
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| 9. Jornada | 16.09.2021 | Santa Tecla FC | - | Alianza | 0:4 | ||||
| 10. Jornada | 19.09.2021 | Alianza | - | CD Águila | 2:1 | ||||
| 12. Jornada | 02.10.2021 | Municipal Limeño | - | Alianza | 0:3 | ||||
| 13. Jornada | 17.10.2021 | Alianza | - | Platense Zacatecoluca | 4:0 | ||||
| 21. Jornada | 21.11.2021 | CD Águila | - | Alianza | 0:1 |
El Salvador