| 1. Jornada | 08.01.2012 | Puebla FC | - | Atlas Guadalajara | 0:0 | ||||
| 2. Jornada | 15.01.2012 | CF Pachuca | - | Puebla FC | 3:1 | ||||
| 3. Jornada | 22.01.2012 | Puebla FC | - | Atlante | 1:2 |  |
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| 4. Jornada | 29.01.2012 | Jaguares Chiapas | - | Puebla FC | 0:1 | |
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| 5. Jornada | 05.02.2012 | Puebla FC | - | Club Tijuana | 1:1 | |
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| 6. Jornada | 12.02.2012 | Pumas UNAM | - | Puebla FC | 0:2 | ||||
| 7. Jornada | 19.02.2012 | Puebla FC | - | Monarcas Morelia | 1:2 | ||||
| 8. Jornada | 26.02.2012 | CF Monterrey | - | Puebla FC | 2:1 | ||||
| 9. Jornada | 04.03.2012 | Puebla FC | - | Deportivo Guadalajara | 1:2 | |
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| 10. Jornada | 11.03.2012 | Santos Laguna | - | Puebla FC | 3:1 | ||||
| 11. Jornada | 18.03.2012 | Puebla FC | - | Club San Luis | 0:1 | |
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| 12. Jornada | 25.03.2012 | Puebla FC | - | Cruz Azul | 1:1 | ||||
| 13. Jornada | 01.04.2012 | Gallos Blancos (old) | - | Puebla FC | 0:1 | ||||
| 14. Jornada | 08.04.2012 | Puebla FC | - | Deportivo Toluca | 2:1 | ||||
| 15. Jornada | 14.04.2012 | Estudiantes Tecos | - | Puebla FC | 1:1 | ||||
| 16. Jornada | 22.04.2012 | Puebla FC | - | CF América | 2:3 | ||||
| 17. Jornada | 29.04.2012 | UANL Tigres | - | Puebla FC | 1:2 |
Uruguay