| 1. Jornada | 11.01.2025 | Deportivo Guadalajara [Sub 23] | - | Santos Laguna [Sub 23] | 0:2 | ||||
| 4. Jornada | 29.01.2025 | FC Juárez [Sub 23] | - | Santos Laguna [Sub 23] | 0:0 | ||||
| 6. Jornada | 07.02.2025 | Club Necaxa [Sub 23] | - | Santos Laguna [Sub 23] | 0:1 | ||||
| 7. Jornada | 14.02.2025 | Mazatlán FC [Sub 23] | - | Santos Laguna [Sub 23] | 1:5 | ||||
| 9. Jornada | 19.02.2025 | Santos Laguna [Sub 23] | - | Cruz Azul [Sub 23] | 0:2 |  |
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| 8. Jornada | 23.02.2025 | Santos Laguna [Sub 23] | - | Atlas Guadalajara [Sub 23] | 2:0 | ||||
| 10. Jornada | 02.03.2025 | CF Monterrey [Sub 23] | - | Santos Laguna [Sub 23] | 3:2 | |
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| 11. Jornada | 09.03.2025 | Santos Laguna [Sub 23] | - | Club León [Sub 23] | 2:0 | |
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| 12. Jornada | 15.03.2025 | UANL Tigres [Sub 23] | - | Santos Laguna [Sub 23] | 3:1 |
México