| 2. Jornada | 12.09.2021 | AEK Larnaca | - | Omonia Nikosia | 2:1 |  |
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| 3. Jornada | 20.09.2021 | Omonia Nikosia | - | Doxa Katokopias | 2:1 |  |
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| 6. Jornada | 17.10.2021 | Omonia Nikosia | - | Apollon Limassol | 1:0 | ||||
| 7. Jornada | 25.10.2021 | PAEEK | - | Omonia Nikosia | 1:0 | ||||
| 8. Jornada | 29.10.2021 | Omonia Nikosia | - | Anorthosis Famagusta | 0:1 | ||||
| 10. Jornada | 21.11.2021 | Omonia Nikosia | - | Aris Limassol | 3:0 | |
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| 12. Jornada | 05.12.2021 | AEL Limassol | - | Omonia Nikosia | 0:1 | ||||
| 13. Jornada | 13.12.2021 | Omonia Nikosia | - | AEK Larnaca | 1:1 | ||||
| 11. Jornada | 26.12.2021 | APOEL Nikosia | - | Omonia Nikosia | 4:2 | |
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| 15. Jornada | 05.01.2022 | Paphos FC | - | Omonia Nikosia | 1:1 |  |
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| 17. Jornada | 16.01.2022 | Apollon Limassol | - | Omonia Nikosia | 2:0 | ||||
| 18. Jornada | 24.01.2022 | Omonia Nikosia | - | PAEEK | 2:1 | ||||
| 19. Jornada | 29.01.2022 | Anorthosis Famagusta | - | Omonia Nikosia | 1:1 |
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