| 3. Jornada | 08.08.2021 | FC Luzern | - | FC Zürich | 1:3 |  |
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| 4. Jornada | 22.08.2021 | Servette FC | - | FC Luzern | 4:1 | ||||
| 5. Jornada | 29.08.2021 | FC Luzern | - | FC Lausanne-Sport | 1:1 | ||||
| 6. Jornada | 11.09.2021 | FC Luzern | - | Grasshopper Club Zürich | 1:1 | ||||
| 7. Jornada | 23.09.2021 | FC Sion | - | FC Luzern | 1:1 | ||||
| 8. Jornada | 26.09.2021 | FC Luzern | - | FC Lugano | 2:3 | ||||
| 9. Jornada | 03.10.2021 | Basilea | - | FC Luzern | 1:1 |  |
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| 10. Jornada | 16.10.2021 | BSC Young Boys | - | FC Luzern | 1:1 | ||||
| 11. Jornada | 24.10.2021 | FC Luzern | - | FC St. Gallen | 2:0 | |
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| 12. Jornada | 31.10.2021 | FC Lausanne-Sport | - | FC Luzern | 1:1 | ||||
| 13. Jornada | 06.11.2021 | FC Luzern | - | FC Sion | 0:1 | |
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| 14. Jornada | 21.11.2021 | FC Lugano | - | FC Luzern | 3:1 | ||||
| 15. Jornada | 28.11.2021 | FC Luzern | - | Basilea | 1:3 | ||||
| 17. Jornada | 12.12.2021 | Grasshopper Club Zürich | - | FC Luzern | 1:1 | ||||
| 18. Jornada | 18.12.2021 | FC Luzern | - | Servette FC | 0:2 | ||||
| 20. Jornada | 06.02.2022 | FC Lugano | - | FC Luzern | 2:1 | ||||
| 28. Jornada | 03.04.2022 | FC Luzern | - | FC Lugano | 2:2 | |
Países Bajos