| 1. Jornada | 12.03.2021 | Real Tomayapo | - | Always Ready | 1:0 | ||||
| 2. Jornada | 14.03.2021 | Always Ready | - | Club San José | 5:0 | ||||
| 3. Jornada | 03.04.2021 | Real Santa Cruz | - | Always Ready | 2:3 | ||||
| 9. Jornada | 18.07.2021 | Independiente Petrolero | - | Always Ready | 1:2 | ||||
| 10. Jornada | 21.07.2021 | Royal Pari | - | Always Ready | 2:1 | ||||
| 11. Jornada | 24.07.2021 | Always Ready | - | Real Potosí | 2:1 | ||||
| 12. Jornada | 01.08.2021 | CD Guabirá | - | Always Ready | 0:0 | ||||
| 13. Jornada | 04.08.2021 | Always Ready | - | Blooming | 5:1 | ||||
| 14. Jornada | 09.08.2021 | Bolívar | - | Always Ready | 0:2 | ||||
| 6. Jornada | 11.08.2021 | Always Ready | - | The Strongest | 2:1 | ||||
| 18. Jornada | 14.09.2021 | Always Ready | - | Real Santa Cruz | 4:0 | ||||
| 24. Jornada | 27.10.2021 | Always Ready | - | Independiente Petrolero | 2:2 | ||||
| 25. Jornada | 31.10.2021 | Always Ready | - | Royal Pari | 2:1 | ||||
| 26. Jornada | 21.11.2021 | Real Potosí | - | Always Ready | 3:2 | ||||
| 27. Jornada | 27.11.2021 | Always Ready | - | CD Guabirá | 6:1 | ||||
| 28. Jornada | 01.12.2021 | Blooming | - | Always Ready | 1:2 |  |
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| 29. Jornada | 05.12.2021 | Always Ready | - | Bolívar | 1:1 | ||||
| 30. Jornada | 12.12.2021 | Club Aurora | - | Always Ready | 3:4 |
Bolivia