| 1. Jornada | 16.01.2022 | Once Municipal | - | FAS | 1:1 | ||||
| 2. Jornada | 23.01.2022 | Santa Tecla FC | - | Once Municipal | 1:1 | ||||
| 3. Jornada | 26.01.2022 | Once Municipal | - | Municipal Limeño | 3:2 | ||||
| 4. Jornada | 30.01.2022 | Atlético Marte | - | Once Municipal | 1:1 | ||||
| 5. Jornada | 06.02.2022 | Once Municipal | - | Isidro Metapán | 0:0 | ||||
| 6. Jornada | 10.02.2022 | AD Chalatenango | - | Once Municipal | 1:0 | ||||
| 7. Jornada | 13.02.2022 | Once Municipal | - | Luis Ángel Firpo | 1:0 | ||||
| 8. Jornada | 20.02.2022 | Platense Zacatecoluca | - | Once Municipal | 1:0 | ||||
| 9. Jornada | 23.02.2022 | Once Municipal | - | Alianza | 1:2 | ||||
| 10. Jornada | 27.02.2022 | Once Municipal | - | CD Águila | 1:4 | ||||
| 16. Jornada | 10.04.2022 | Isidro Metapán | - | Once Municipal | 2:2 | ||||
| 18. Jornada | 17.04.2022 | Luis Ángel Firpo | - | Once Municipal | 0:0 | ||||
| 19. Jornada | 24.04.2022 | Once Municipal | - | Platense Zacatecoluca | 1:2 | ||||
| 20. Jornada | 29.04.2022 | Alianza | - | Once Municipal | 1:0 | ||||
| 21. Jornada | 01.05.2022 | CD Águila | - | Once Municipal | 0:1 |
El Salvador