| 3. Jornada | 22.01.2021 | Atlético San Luis | - | Deportivo Guadalajara | 3:1 | ||||
| 4. Jornada | 02.02.2021 | Club León | - | Atlético San Luis | 3:1 | ||||
| 5. Jornada | 05.02.2021 | Atlético San Luis | - | Club Tijuana | 2:2 | ||||
| 6. Jornada | 13.02.2021 | Mazatlán FC | - | Atlético San Luis | 0:3 | ||||
| 7. Jornada | 19.02.2021 | Atlético San Luis | - | Santos Laguna | 1:0 | ||||
| 9. Jornada | 03.03.2021 | Atlas Guadalajara | - | Atlético San Luis | 3:1 |
México