| 2. Jornada | 16.01.2022 | LD Alajuelense | - | Guadalupe | 1:0 | ||||
| 4. Jornada | 04.02.2022 | Guadalupe | - | AD San Carlos | 3:1 | ||||
| 9. Jornada | 03.03.2022 | Municipal Pérez Zeledón | - | Guadalupe | 0:1 |  |
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| 11. Jornada | 01.04.2022 | AD Guanacasteca | - | Guadalupe | 1:2 | ||||
| 12. Jornada | 08.04.2022 | CS Cartaginés | - | Guadalupe | 4:1 | ||||
| 14. Jornada | 17.04.2022 | Guadalupe | - | Sporting FC | 4:2 | ||||
| 15. Jornada | 20.04.2022 | AD San Carlos | - | Guadalupe | 2:1 | |
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| 16. Jornada | 24.04.2022 | Municipal Grecia | - | Guadalupe | 3:2 | ||||
| 18. Jornada | 01.05.2022 | Santos de Guápiles | - | Guadalupe | 6:0 | ||||
| 21. Jornada | 13.05.2022 | CS Herediano | - | Guadalupe | 0:0 | ||||
| 22. Jornada | 15.05.2022 | Guadalupe | - | AD Guanacasteca | 0:0 | |
Costa Rica