| 1. Jornada | 06.01.2022 | Atlético San Luis [Sub 20] | - | CF Pachuca [Sub 20] | 0:2 | ||||
| 4. Jornada | 05.02.2022 | CF América [Sub 20] | - | Atlético San Luis [Sub 20] | 0:1 | ||||
| 7. Jornada | 26.02.2022 | CF Monterrey [Sub 20] | - | Atlético San Luis [Sub 20] | 1:3 | ||||
| 11. Jornada | 17.03.2022 | Gallos Blancos [Sub 20] | - | Atlético San Luis [Sub 20] | 3:0 | ||||
| 12. Jornada | 01.04.2022 | Atlético San Luis [Sub 20] | - | Mazatlán FC [Sub 20] | 1:2 | ||||
| 9. Jornada | 06.04.2022 | Club Tijuana [Sub 20] | - | Atlético San Luis [Sub 20] | 2:1 | ||||
| 14. Jornada | 15.04.2022 | Club Necaxa [Sub 20] | - | Atlético San Luis [Sub 20] | 3:0 |
México