| 8. Jornada | 20.09.2021 | Managua FC | - | Real Madriz | 1:1 | ||||
| 6. Jornada | 23.09.2021 | Managua FC | - | Club Deportivo Ocotal | 3:1 |  |
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| 9. Jornada | 27.09.2021 | CD Walter Ferretti | - | Managua FC | 0:0 | ||||
| 10. Jornada | 02.10.2021 | Juventus Managua | - | Managua FC | 1:3 | ||||
| 12. Jornada | 17.10.2021 | Real Estelí FC | - | Managua FC | 1:0 | ||||
| 16. Jornada | 05.11.2021 | Club Deportivo Ocotal | - | Managua FC | 1:0 | ||||
| 18. Jornada | 22.11.2021 | Managua FC | - | CD Walter Ferretti | 3:1 |
Nicaragua