| 1. Jornada | 13.03.2021 | FK Pohronie | - | FK Senica | 3:0 | ||||
| 2. Jornada | 20.03.2021 | FK Senica | - | ŠKF Sereď | 1:0 | ||||
| 3. Jornada | 03.04.2021 | MFK Zemplín Michalovce | - | FK Senica | 1:0 | ||||
| 4. Jornada | 10.04.2021 | FK Senica | - | MFK Ružomberok | 0:1 | ||||
| 5. Jornada | 17.04.2021 | FC Nitra | - | FK Senica | 0:3 | ||||
| 6. Jornada | 24.04.2021 | FK Senica | - | MFK Zemplín Michalovce | 1:1 | ||||
| 7. Jornada | 01.05.2021 | FK Senica | - | FC Nitra | 1:0 | ||||
| 8. Jornada | 08.05.2021 | MFK Ružomberok | - | FK Senica | 1:1 | ||||
| 9. Jornada | 15.05.2021 | FK Senica | - | FK Pohronie | 0:0 | ||||
| 10. Jornada | 22.05.2021 | ŠKF Sereď | - | FK Senica | 4:1 |
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