| 7. Jornada | 20.09.2020 | FK Senica | - | FC DAC 1904 | 2:4 | ||||
| 8. Jornada | 26.09.2020 | FK Senica | - | Spartak Trnava | 0:2 | ||||
| 4. Jornada | 30.09.2020 | Slovan Bratislava | - | FK Senica | 2:0 | ||||
| 9. Jornada | 04.10.2020 | AS Trenčín | - | FK Senica | 0:1 | ||||
| 10. Jornada | 17.10.2020 | FK Senica | - | MFK Ružomberok | 1:2 |  |
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| 13. Jornada | 17.11.2020 | FK Senica | - | ŠKF Sereď | 2:2 | ||||
| 14. Jornada | 21.11.2020 | MFK Zemplín Michalovce | - | FK Senica | 0:1 | ||||
| 15. Jornada | 29.11.2020 | FK Senica | - | Slovan Bratislava | 0:3 | |
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| 16. Jornada | 05.12.2020 | FC Nitra | - | FK Senica | 1:1 | ||||
| 19. Jornada | 13.02.2021 | Spartak Trnava | - | FK Senica | 1:0 | ||||
| 20. Jornada | 20.02.2021 | FK Senica | - | AS Trenčín | 2:3 | |
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| 21. Jornada | 27.02.2021 | MFK Ružomberok | - | FK Senica | 2:3 | ||||
| 22. Jornada | 06.03.2021 | FK Senica | - | FK Pohronie | 1:1 |
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