| 2. Jornada | 22.01.2022 | CSD Municipal | - | Deportivo Guastatoya | 0:0 | ||||
| 6. Jornada | 09.02.2022 | CSD Municipal | - | Xelaju MC | 2:2 | ||||
| 9. Jornada | 27.02.2022 | Iztapa | - | CSD Municipal | 2:1 | ||||
| 10. Jornada | 03.03.2022 | Antigua GFC | - | CSD Municipal | 1:3 | ||||
| 12. Jornada | 12.03.2022 | CSD Municipal | - | Santa Lucía | 2:1 | ||||
| 13. Jornada | 20.03.2022 | Deportivo Guastatoya | - | CSD Municipal | 1:2 | ||||
| 17. Jornada | 17.04.2022 | Xelaju MC | - | CSD Municipal | 0:1 | ||||
| 20. Jornada | 30.04.2022 | CSD Municipal | - | Iztapa | 3:1 | ||||
| 21. Jornada | 04.05.2022 | CSD Municipal | - | Antigua GFC | 0:1 | ||||
| 22. Jornada | 08.05.2022 | Achuapa | - | CSD Municipal | 0:0 |
Guatemala