| 1. Jornada | 25.07.2021 | Pumas UNAM | - | Atlas Guadalajara | 0:0 | ||||
| 2. Jornada | 01.08.2021 | CF Monterrey | - | Pumas UNAM | 2:0 | ||||
| 3. Jornada | 08.08.2021 | Pumas UNAM | - | Atlético San Luis | 1:3 |  |
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| 4. Jornada | 15.08.2021 | Pumas UNAM | - | Gallos Blancos | 0:0 | |
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| 14. Jornada | 21.10.2021 | Club León | - | Pumas UNAM | 1:2 | |
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| 17. Jornada | 08.11.2021 | Pumas UNAM | - | Cruz Azul | 4:3 |
México