| 1. Jornada | 01.08.2021 | Luis Ángel Firpo | - | Jocoro FC | 1:1 |  |
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| 3. Jornada | 04.08.2021 | FAS | - | Jocoro FC | 4:1 | ||||
| 4. Jornada | 14.08.2021 | Jocoro FC | - | Isidro Metapán | 1:0 | ||||
| 5. Jornada | 22.08.2021 | Atlético Marte | - | Jocoro FC | 2:1 | |
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| 6. Jornada | 25.08.2021 | Jocoro FC | - | Santa Tecla FC | 2:0 | |
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| 7. Jornada | 29.08.2021 | CD Águila | - | Jocoro FC | 2:2 |  |
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| 12. Jornada | 02.10.2021 | Jocoro FC | - | Luis Ángel Firpo | 2:1 | ||||
| 13. Jornada | 17.10.2021 | Once Municipal | - | Jocoro FC | 2:2 | |
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| 19. Jornada | 14.11.2021 | AD Chalatenango | - | Jocoro FC | 2:0 | |
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| 20. Jornada | 17.11.2021 | Municipal Limeño | - | Jocoro FC | 0:0 | ||||
| 22. Jornada | 27.11.2021 | Alianza | - | Jocoro FC | 2:0 |
El Salvador