| 1. Jornada | 10.07.2022 | Macará | - | Emelec | 1:3 |  |
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| 2. Jornada | 16.07.2022 | Orense SC | - | Macará | 1:1 | |
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| 3. Jornada | 26.07.2022 | Macará | - | Delfín SC | 1:2 | |
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| 4. Jornada | 31.07.2022 | Macará | - | Universidad Catolica | 1:3 | ||||
| 5. Jornada | 07.08.2022 | Guayaquil City | - | Macará | 0:0 | ||||
| 6. Jornada | 14.08.2022 | Cumbayá | - | Macará | 1:0 | |
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| 7. Jornada | 21.08.2022 | Macará | - | Aucas | 1:1 | ||||
| 8. Jornada | 27.08.2022 | Deportivo Cuenca | - | Macará | 1:1 | |
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| 9. Jornada | 04.09.2022 | Macará | - | Mushuc Runa | 3:0 | ||||
| 11. Jornada | 17.09.2022 | Macará | - | Gualaceo SC | 1:1 | ||||
| 12. Jornada | 25.09.2022 | Independiente del Valle | - | Macará | 1:0 | ||||
| 13. Jornada | 08.10.2022 | Macará | - | 9 de Octubre | 3:1 | |
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| 15. Jornada | 22.10.2022 | Macará | - | LDU Quito | 0:5 | |
Ecuador