| 1. Jornada | 23.07.2022 | Sporting San Miguelito | - | Alianza | 0:1 | ||||
| 2. Jornada | 31.07.2022 | Plaza Amador | - | Sporting San Miguelito | 1:1 | ||||
| 3. Jornada | 08.08.2022 | Sporting San Miguelito | - | Árabe Unido | 0:0 | ||||
| 4. Jornada | 11.08.2022 | Sporting San Miguelito | - | Tauro FC | 3:1 |  |
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| 5. Jornada | 14.08.2022 | Potros del Este | - | Sporting San Miguelito | 1:3 | ||||
| 6. Jornada | 21.08.2022 | Sporting San Miguelito | - | UD Universitario | 2:2 | ||||
| 8. Jornada | 03.09.2022 | Sporting San Miguelito | - | Veraguas United | 3:2 | ||||
| 9. Jornada | 12.09.2022 | Sporting San Miguelito | - | San Francisco FC | 2:1 | ||||
| 10. Jornada | 18.09.2022 | Atlético Chiriquí | - | Sporting San Miguelito | 0:0 | ||||
| 11. Jornada | 24.09.2022 | Independiente de La Chorrera | - | Sporting San Miguelito | 0:2 | ||||
| 12. Jornada | 28.09.2022 | Alianza | - | Sporting San Miguelito | 1:0 | ||||
| 13. Jornada | 02.10.2022 | Sporting San Miguelito | - | Plaza Amador | 1:1 | |
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| 14. Jornada | 08.10.2022 | Árabe Unido | - | Sporting San Miguelito | 1:1 | ||||
| 15. Jornada | 17.10.2022 | Tauro FC | - | Sporting San Miguelito | 2:0 | ||||
| 16. Jornada | 22.10.2022 | Sporting San Miguelito | - | Potros del Este | 3:2 |
Panamá