| 2. Jornada | 17.01.2021 | Pumas UNAM | - | Mazatlán FC | 3:0 | ||||
| 6. Jornada | 13.02.2021 | Mazatlán FC | - | Atlético San Luis | 0:3 | ||||
| 7. Jornada | 20.02.2021 | FC Juárez | - | Mazatlán FC | 1:0 | ||||
| 8. Jornada | 27.02.2021 | Mazatlán FC | - | Gallos Blancos | 3:0 | ||||
| 9. Jornada | 04.03.2021 | Cruz Azul | - | Mazatlán FC | 1:0 |  |
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| 10. Jornada | 07.03.2021 | Mazatlán FC | - | Deportivo Guadalajara | 1:1 | |
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| 11. Jornada | 14.03.2021 | UANL Tigres | - | Mazatlán FC | 1:2 | |
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| 12. Jornada | 20.03.2021 | Mazatlán FC | - | CF América | 0:1 | ||||
| 13. Jornada | 03.04.2021 | Puebla FC | - | Mazatlán FC | 3:1 | ||||
| 14. Jornada | 12.04.2021 | Club Tijuana | - | Mazatlán FC | 2:3 | |
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| 15. Jornada | 17.04.2021 | Mazatlán FC | - | Atlas Guadalajara | 0:0 | ||||
| 16. Jornada | 24.04.2021 | Mazatlán FC | - | Club León | 4:3 | ||||
| 17. Jornada | 02.05.2021 | CF Monterrey | - | Mazatlán FC | 1:0 | |
Colombia