| 1. Jornada | 27.01.2018 | Club San José | - | Nacional Potosí | 1:2 | ||||
| 2. Jornada | 03.02.2018 | The Strongest | - | Club San José | 1:1 | ||||
| 3. Jornada | 07.02.2018 | Club San José | - | Royal Pari | 3:0 | ||||
| 4. Jornada | 17.02.2018 | Sport Boys Warnes | - | Club San José | 0:0 | ||||
| 5. Jornada | 25.02.2018 | Club San José | - | Blooming | 4:0 | ||||
| 6. Jornada | 03.03.2018 | Club Aurora | - | Club San José | 1:1 | ||||
| 9. Jornada | 18.03.2018 | Club San José | - | The Strongest | 3:1 | ||||
| 7. Jornada | 25.03.2018 | Club San José | - | Universitario de Sucre | 2:1 | ||||
| 10. Jornada | 31.03.2018 | Royal Pari | - | Club San José | 0:2 | ||||
| 11. Jornada | 08.04.2018 | Club San José | - | Sport Boys Warnes | 4:0 | ||||
| 14. Jornada | 29.04.2018 | Universitario de Sucre | - | Club San José | 1:2 |  |
Uruguay