| 2. Jornada | 15.03.2021 | Blooming | - | Independiente Petrolero | 2:2 | ||||
| 1. Jornada | 21.03.2021 | Blooming | - | CD Guabirá | 0:1 | ||||
| 4. Jornada | 10.04.2021 | Blooming | - | Club Aurora | 1:0 | ||||
| 6. Jornada | 04.05.2021 | Blooming | - | Club San José | 4:0 | ||||
| 7. Jornada | 07.05.2021 | Real Santa Cruz | - | Blooming | 1:0 | ||||
| 8. Jornada | 13.07.2021 | Blooming | - | Nacional Potosí | 2:1 | ||||
| 9. Jornada | 18.07.2021 | Oriente Petrolero | - | Blooming | 3:0 |  |
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| 10. Jornada | 22.07.2021 | Blooming | - | The Strongest | 2:0 | ||||
| 11. Jornada | 27.07.2021 | Jorge Wilstermann | - | Blooming | 2:1 | ||||
| 14. Jornada | 10.08.2021 | Blooming | - | Royal Pari | 0:1 | ||||
| 15. Jornada | 14.08.2021 | Real Potosí | - | Blooming | 3:1 | ||||
| 16. Jornada | 18.08.2021 | CD Guabirá | - | Blooming | 4:2 | ||||
| 20. Jornada | 22.09.2021 | Blooming | - | Real Tomayapo | 0:1 | ||||
| 22. Jornada | 18.10.2021 | Blooming | - | Real Santa Cruz | 3:1 | ||||
| 23. Jornada | 24.10.2021 | Nacional Potosí | - | Blooming | 4:0 | ||||
| 27. Jornada | 27.11.2021 | Atlético Palmaflor | - | Blooming | 3:0 | ||||
| 28. Jornada | 01.12.2021 | Blooming | - | Always Ready | 1:2 |
Bolivia