| 1. Jornada | 25.07.2021 | Tigres FC | - | Bogotá FC | 0:0 |  |
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| 2. Jornada | 30.07.2021 | Atlético FC | - | Tigres FC | 2:1 | ||||
| 3. Jornada | 07.08.2021 | Tigres FC | - | Orsomarso SC | 1:2 | ||||
| 7. Jornada | 06.09.2021 | Tigres FC | - | Real Santander | 2:0 | ||||
| 8. Jornada | 10.09.2021 | Cortuluá | - | Tigres FC | 3:0 | |
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| 9. Jornada | 22.09.2021 | Tigres FC | - | Unión Magdalena | 0:0 | ||||
| 11. Jornada | 06.10.2021 | Tigres FC | - | Real Cartagena | 1:2 |  |
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| 12. Jornada | 12.10.2021 | Leones FC | - | Tigres FC | 2:0 | |
Colombia