| 1. Jornada | 09.08.2021 | Honduras Progreso | - | Marathón | 1:2 |  |
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| 2. Jornada | 13.08.2021 | Platense | - | Honduras Progreso | 1:1 | ||||
| 3. Jornada | 15.08.2021 | Lobos UPNFM | - | Honduras Progreso | 3:0 | ||||
| 4. Jornada | 22.08.2021 | Honduras Progreso | - | Victoria | 2:0 |  |
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| 5. Jornada | 26.08.2021 | Olimpia | - | Honduras Progreso | 2:1 | ||||
| 6. Jornada | 29.08.2021 | Honduras Progreso | - | Vida | 1:1 | ||||
| 7. Jornada | 05.09.2021 | Honduras Progreso | - | Motagua | 0:3 |  |
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| 9. Jornada | 16.09.2021 | Honduras Progreso | - | Real España | 1:1 | ||||
| 10. Jornada | 20.09.2021 | Vida | - | Honduras Progreso | 1:0 | ||||
| 11. Jornada | 23.09.2021 | Victoria | - | Honduras Progreso | 1:2 | |
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| 12. Jornada | 03.10.2021 | Honduras Progreso | - | Platense | 4:2 | ||||
| 13. Jornada | 09.10.2021 | Marathón | - | Honduras Progreso | 2:1 | |
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| 15. Jornada | 24.10.2021 | Honduras Progreso | - | Olimpia | 0:2 | |
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| 16. Jornada | 28.10.2021 | Real España | - | Honduras Progreso | 4:1 | ||||
| 17. Jornada | 01.11.2021 | Honduras Progreso | - | Real Sociedad | 2:1 | |
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| 18. Jornada | 10.11.2021 | Motagua | - | Honduras Progreso | 3:2 |
Colombia