| 4. Jornada | 14.08.2021 | Club Tijuana [Sub 16] | - | FC Juárez [Sub 16] | 1:1 | ||||
| 2. Jornada | 15.09.2021 | Club Tijuana [Sub 16] | - | Deportivo Toluca [Sub 16] | 3:0 | ||||
| 9. Jornada | 18.09.2021 | Club Tijuana [Sub 16] | - | Pumas UNAM [Sub 16] | 1:0 | ||||
| 12. Jornada | 09.10.2021 | Club Tijuana [Sub 16] | - | Puebla FC [Sub 16] | 3:1 | ||||
| 13. Jornada | 16.10.2021 | CF América [Sub 16] | - | Club Tijuana [Sub 16] | 4:2 | ||||
| 14. Jornada | 23.10.2021 | Club Tijuana [Sub 16] | - | CF Pachuca [Sub 16] | 0:1 | ||||
| 15. Jornada | 30.10.2021 | Club Tijuana [Sub 16] | - | Gallos Blancos [Sub 16] | 3:2 | ||||
| 16. Jornada | 06.11.2021 | FC Juárez [Sub 16] | - | Club Tijuana [Sub 16] | 1:3 | ||||
| 17. Jornada | 13.11.2021 | Pumas UNAM [Sub 16] | - | Club Tijuana [Sub 16] | 0:0 | ||||
| 18. Jornada | 20.11.2021 | Club Tijuana [Sub 16] | - | Cruz Azul [Sub 16] | 0:0 |  |
México