| 1. Jornada | 09.01.2021 | Mazatlán FC | - | Club Necaxa | 3:2 |  |
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| 3. Jornada | 24.01.2021 | Deportivo Toluca | - | Club Necaxa | 2:0 | ||||
| 7. Jornada | 20.02.2021 | Club Necaxa | - | CF Monterrey | 1:1 | ||||
| 8. Jornada | 27.02.2021 | Puebla FC | - | Club Necaxa | 1:0 | ||||
| 9. Jornada | 05.03.2021 | Club Necaxa | - | CF Pachuca | 2:2 |  |
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| 10. Jornada | 08.03.2021 | Santos Laguna | - | Club Necaxa | 3:1 | ||||
| 11. Jornada | 16.03.2021 | Club León | - | Club Necaxa | 3:1 | ||||
| 12. Jornada | 20.03.2021 | Club Necaxa | - | FC Juárez | 1:0 | ||||
| 13. Jornada | 04.04.2021 | CF América | - | Club Necaxa | 2:1 | ||||
| 14. Jornada | 10.04.2021 | Club Necaxa | - | Pumas UNAM | 0:1 | |
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| 15. Jornada | 17.04.2021 | Club Necaxa | - | Gallos Blancos | 0:0 | ||||
| 16. Jornada | 24.04.2021 | Club Tijuana | - | Club Necaxa | 1:0 | ||||
| 17. Jornada | 01.05.2021 | Club Necaxa | - | Atlas Guadalajara | 1:5 | |
Chile