| 2. Jornada | 15.03.2021 | Blooming | - | Independiente Petrolero | 2:2 | ||||
| 8. Jornada | 13.07.2021 | Blooming | - | Nacional Potosí | 2:1 |  |
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| 9. Jornada | 18.07.2021 | Oriente Petrolero | - | Blooming | 3:0 | |
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| 11. Jornada | 27.07.2021 | Jorge Wilstermann | - | Blooming | 2:1 | ||||
| 12. Jornada | 31.07.2021 | Blooming | - | Atlético Palmaflor | 1:1 | ||||
| 18. Jornada | 15.09.2021 | Blooming | - | Bolívar | 2:2 | ||||
| 19. Jornada | 18.09.2021 | Club Aurora | - | Blooming | 2:0 | ||||
| 20. Jornada | 22.09.2021 | Blooming | - | Real Tomayapo | 0:1 | ||||
| 21. Jornada | 25.09.2021 | Club San José | - | Blooming | 1:2 | |
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| 24. Jornada | 28.10.2021 | Blooming | - | Oriente Petrolero | 1:1 | ||||
| 25. Jornada | 30.10.2021 | The Strongest | - | Blooming | 2:1 | ||||
| 26. Jornada | 22.11.2021 | Blooming | - | Jorge Wilstermann | 2:2 | ||||
| 28. Jornada | 01.12.2021 | Blooming | - | Always Ready | 1:2 | ||||
| 29. Jornada | 05.12.2021 | Royal Pari | - | Blooming | 4:3 | ||||
| 30. Jornada | 12.12.2021 | Blooming | - | Real Potosí | 1:0 |
Bolivia