| 1. Jornada | 07.11.2021 | Anagennisi Karditsa | - | Thesprotos | 1:0 | ||||
| 3. Jornada | 21.11.2021 | Anagennisi Karditsa | - | Almopos Arideas | 4:0 |  |
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| 4. Jornada | 25.11.2021 | Niki Volou FC | - | Anagennisi Karditsa | 1:0 | ||||
| 5. Jornada | 28.11.2021 | Anagennisi Karditsa | - | Olympiacos Volou | 4:0 | ||||
| 16. Jornada | 30.01.2022 | Anagennisi Karditsa | - | Pierikos Katerini | 2:0 | ||||
| 11. Jornada | 02.02.2022 | Anagennisi Karditsa | - | Panserraikos | 1:0 | |
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| 17. Jornada | 06.02.2022 | Xanthi FC | - | Anagennisi Karditsa | 5:2 | |
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| 18. Jornada | 13.02.2022 | Thesprotos | - | Anagennisi Karditsa | 0:0 | ||||
| 19. Jornada | 16.02.2022 | Anagennisi Karditsa | - | AO Kavala | 1:0 | |
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| 20. Jornada | 20.02.2022 | Almopos Arideas | - | Anagennisi Karditsa | 1:0 | ||||
| 12. Jornada | 23.02.2022 | AEP Iraklis FC | - | Anagennisi Karditsa | 1:1 |  |
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| 13. Jornada | 02.03.2022 | Anagennisi Karditsa | - | Veria FC | 5:2 | |
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| 22. Jornada | 06.03.2022 | Olympiacos Volou | - | Anagennisi Karditsa | 0:1 | |
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| 25. Jornada | 19.03.2022 | Anagennisi Karditsa | - | AE Lárissa | 2:3 |  |
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| 30. Jornada | 10.04.2022 | Veria FC | - | Anagennisi Karditsa | 2:0 |
Argentina