| 4. Jornada | 13.02.2022 | Real Santander | - | Barranquilla FC | 2:3 | ||||
| 8. Jornada | 10.03.2022 | Orsomarso SC | - | Barranquilla FC | 2:1 | ||||
| 10. Jornada | 26.03.2022 | Deportes Quindío | - | Barranquilla FC | 2:1 | ||||
| 12. Jornada | 11.04.2022 | Boca Juniors de Cali | - | Barranquilla FC | 0:0 | ||||
| 14. Jornada | 25.04.2022 | Tigres FC | - | Barranquilla FC | 2:0 |
Colombia