| 1. Jornada | 21.07.2018 | Boston River | - | River Plate | 2:3 | ||||
| 2. Jornada | 29.07.2018 | River Plate | - | Peñarol | 0:1 | ||||
| 3. Jornada | 04.08.2018 | Atenas | - | River Plate | 1:1 | ||||
| 4. Jornada | 12.08.2018 | River Plate | - | Danubio | 1:2 | ||||
| 5. Jornada | 19.08.2018 | Torque | - | River Plate | 3:0 | ||||
| 6. Jornada | 26.08.2018 | River Plate | - | Rampla Juniors | 3:4 | ||||
| 7. Jornada | 01.09.2018 | Fénix | - | River Plate | 1:3 |  |
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| 8. Jornada | 09.09.2018 | River Plate | - | Nacional | 0:0 | ||||
| 9. Jornada | 16.09.2018 | Progreso | - | River Plate | 2:2 |  |
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| 10. Jornada | 23.09.2018 | River Plate | - | Defensor Sporting | 3:2 | |
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| 11. Jornada | 07.10.2018 | Racing | - | River Plate | 2:1 | ||||
| 12. Jornada | 14.10.2018 | CA Cerro | - | River Plate | 4:2 | |
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| 13. Jornada | 21.10.2018 | River Plate | - | Montevideo Wanderers | 0:5 | ||||
| 14. Jornada | 28.10.2018 | Liverpool | - | River Plate | 4:1 |
Uruguay