| 1. Jornada | 01.02.2025 | Real Santander | - | Tigres FC | 1:0 |  |
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| 2. Jornada | 11.02.2025 | Barranquilla FC | - | Real Santander | 1:2 | ||||
| 3. Jornada | 15.02.2025 | Real Santander | - | Real Soacha Cundinamarca | 3:4 | |
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| 4. Jornada | 22.02.2025 | Bogotá FC | - | Real Santander | 2:1 | |
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| 7. Jornada | 17.03.2025 | Real Santander | - | Leones FC | 1:0 |  |
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| 10. Jornada | 06.04.2025 | Real Santander | - | Orsomarso SC | 0:0 | ||||
| 11. Jornada | 14.04.2025 | Atlético FC | - | Real Santander | 2:0 | |
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| 12. Jornada | 19.04.2025 | Real Santander | - | Patriotas FC | 1:1 | ||||
| 13. Jornada | 27.04.2025 | Deportes Quindío | - | Real Santander | 4:2 | ||||
| 14. Jornada | 06.05.2025 | Cúcuta Deportivo | - | Real Santander | 2:1 | |
Colombia