| 8. Jornada | 10.03.2022 | Atlético FC | - | Real Santander | 0:1 | ||||
| 9. Jornada | 21.03.2022 | Real Santander | - | Leones FC | 0:4 |  |
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| 10. Jornada | 26.03.2022 | Bogotá FC | - | Real Santander | 2:1 | ||||
| 12. Jornada | 10.04.2022 | Llaneros FC | - | Real Santander | 2:2 | ||||
| 13. Jornada | 16.04.2022 | Real Santander | - | Deportes Quindío | 0:1 | ||||
| 14. Jornada | 26.04.2022 | Boyacá Chicó | - | Real Santander | 2:1 | ||||
| 15. Jornada | 03.05.2022 | Real Santander | - | Boca Juniors de Cali | 1:1 |
Colombia