| 1. Jornada | 17.01.2021 | Atlético Junior | - | Independiente Medellín | 1:0 | ||||
| 2. Jornada | 25.01.2021 | Once Caldas | - | Atlético Junior | 1:2 | ||||
| 3. Jornada | 31.01.2021 | Atlético Junior | - | América de Cali | 2:1 |  |
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| 5. Jornada | 06.02.2021 | Atlético Junior | - | Alianza Petrolera | 2:0 | ||||
| 6. Jornada | 14.02.2021 | Envigado FC | - | Atlético Junior | 2:2 | ||||
| 7. Jornada | 18.02.2021 | Atlético Junior | - | Deportivo Cali | 1:2 |  |
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| 8. Jornada | 21.02.2021 | Boyacá Chicó | - | Atlético Junior | 2:1 | ||||
| 9. Jornada | 24.02.2021 | Atlético Junior | - | Millonarios | 2:0 | |
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| 10. Jornada | 28.02.2021 | Patriotas FC | - | Atlético Junior | 1:0 | ||||
| 11. Jornada | 06.03.2021 | Atlético Junior | - | Atlético Bucaramanga | 1:1 | |
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| 16. Jornada | 31.03.2021 | Jaguares de Córdoba | - | Atlético Junior | 0:2 | ||||
| 18. Jornada | 12.04.2021 | Deportivo Pasto | - | Atlético Junior | 0:0 |
Colombia